Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions
Identifieur interne : 003112 ( Main/Corpus ); précédent : 003111; suivant : 003113Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions
Auteurs : Gabriella Santangelo ; Carmine Vitale ; Luigi Trojano ; Danilo De Gaspari ; Leonilda Bilo ; Angelo Antonini ; Paolo BaroneSource :
- Movement Disorders [ 0885-3185 ] ; 2010-01-15.
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Abstract
The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22893
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Gaspari D" first="Danilo" last="De Gaspari">Danilo De Gaspari</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bilo, Leonilda" sort="Bilo, Leonilda" uniqKey="Bilo L" first="Leonilda" last="Bilo">Leonilda Bilo</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</mods:affiliation></affiliation></author><author><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name><affiliation><mods:affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Department of Neurological Sciences, University of Naples Federico 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Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Gabriella Santangelo PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string><json:string>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</json:string><json:string>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Carmine Vitale MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string><json:string>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</json:string><json:string>Faculty of Sciences of Movement, University of Naples, “Parthenope,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Luigi Trojano MD</name><affiliations><json:string>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</json:string></affiliations></json:item><json:item><name>Danilo De Gaspari MS</name><affiliations><json:string>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Leonilda Bilo MD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string></affiliations></json:item><json:item><name>Angelo Antonini MD</name><affiliations><json:string>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD, PhD</name><affiliations><json:string>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cerebrovascular lesions</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dopaminergic denervation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cognitive functions</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frontal lobe functions</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item></subject><articleId><json:string>MDS22893</json:string></articleId><language><json:string>eng</json:string></language><abstract>The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. 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No. MIUR‐2006065350‐003;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions</title><author><persName><forename type="first">Gabriella</forename><surname>Santangelo</surname></persName><roleName type="degree">PhD</roleName><note type="biography">The first two authors contributed equally to this work.</note><affiliation>The first two authors contributed equally to this work.</affiliation><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation></author><author><persName><forename type="first">Carmine</forename><surname>Vitale</surname></persName><roleName type="degree">MD, PhD</roleName><note type="biography">The first two authors contributed equally to this work.</note><affiliation>The first two authors contributed equally to this work.</affiliation><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><affiliation>Faculty of Sciences of Movement, University of Naples, “Parthenope,” Naples, Italy</affiliation></author><author><persName><forename type="first">Luigi</forename><surname>Trojano</surname></persName><roleName type="degree">MD</roleName><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation></author><author><persName><forename type="first">Danilo</forename><surname>De Gaspari</surname></persName><roleName type="degree">MS</roleName><affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Leonilda</forename><surname>Bilo</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation></author><author><persName><forename type="first">Angelo</forename><surname>Antonini</surname></persName><roleName type="degree">MD</roleName><affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</affiliation></author><author><persName><forename type="first">Paolo</forename><surname>Barone</surname></persName><roleName type="degree">MD, PhD</roleName><note type="correspondence"><p>Correspondence: Department of Neurological Sciences, University of Naples Federico II, Via S. 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Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="10"><doi origin="wiley" registered="yes">10.1002/mds.v25:1</doi><numberingGroup><numbering type="journalVolume" number="25">25</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2010-01-15">15 January 2010</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="7" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22893</doi><idGroup><id type="unit" value="MDS22893"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2009-03-11"></event><event type="manuscriptRevised" date="2009-10-14"></event><event type="manuscriptAccepted" date="2009-10-17"></event><event type="firstOnline" date="2009-12-11"></event><event type="publishedOnlineFinalForm" date="2010-01-25"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2009-12-11"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.1.9 mode:FullText" date="2013-01-28"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">50</numbering><numbering type="pageLast">56</numbering></numberingGroup><correspondenceTo>Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22893.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="42"></count><count type="wordTotal" number="5440"></count></countGroup><titleGroup><title type="main" xml:lang="en">Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions<link href="#fn1"></link></title><title type="short" xml:lang="en">Cognitive Profile in Vascular Parkinsonism</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3" noteRef="#fn2"><personName><givenNames>Gabriella</givenNames><familyName>Santangelo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3 #af4" noteRef="#fn2"><personName><givenNames>Carmine</givenNames><familyName>Vitale</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Luigi</givenNames><familyName>Trojano</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Danilo</givenNames><familyName>De Gaspari</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Leonilda</givenNames><familyName>Bilo</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af5"><personName><givenNames>Angelo</givenNames><familyName>Antonini</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>barone@unina.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="IT" type="organization"><unparsedAffiliation>Faculty of Sciences of Movement, University of Naples, “Parthenope,” Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">cerebrovascular lesions</keyword><keyword xml:id="kwd2">dopaminergic denervation</keyword><keyword xml:id="kwd3">cognitive functions</keyword><keyword xml:id="kwd4">frontal lobe functions</keyword><keyword xml:id="kwd5">Parkinson's disease</keyword></keywordGroup><fundingInfo><fundingAgency>Italian Ministry of University and Research</fundingAgency><fundingNumber>MIUR‐2006065350‐003</fundingNumber></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note><note xml:id="fn2"><p>The first two authors contributed equally to this work.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cognitive Profile in Vascular Parkinsonism</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Differential neuropsychological profiles in Parkinsonian patients with or without vascular lesions</title></titleInfo><name type="personal"><namePart type="given">Gabriella</namePart><namePart type="family">Santangelo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><description>The first two authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmine</namePart><namePart type="family">Vitale</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><affiliation>Faculty of Sciences of Movement, University of Naples, “Parthenope,” Naples, Italy</affiliation><description>The first two authors contributed equally to this work.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Trojano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Neuropsychology Laboratory, Department of Psychology, Second University of Naples, Caserta, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Danilo</namePart><namePart type="family">De Gaspari</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Leonilda</namePart><namePart type="family">Bilo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angelo</namePart><namePart type="family">Antonini</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Parkinson Institute, Istituti Clinici do Perfezionamento, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurological Sciences, University of Naples Federico II, Naples, Italy</affiliation><description>Correspondence: Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2010-01-15</dateIssued><dateCaptured encoding="w3cdtf">2009-03-11</dateCaptured><dateValid encoding="w3cdtf">2009-10-17</dateValid><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">42</extent><extent unit="words">5440</extent></physicalDescription><abstract lang="en">The purpose of this study is to compare the neuropsychological profile of patients affected by parkinsonism and vascular lesions to that in patients with PD alone (PD) and to evaluate whether the brain vascular lesion load is associated with neuropsychological variables. Thirty‐six nondemented patients with parkinsonism were divided into 3 groups of 12 patients each, according to both clinical history and the presence of brain vascular lesions and/or dopaminergic denervation as revealed by magnetic resonance and dopamine transporter imaging, respectively. The first group had vascular lesions without dopaminergic denervation (VP group); the second group had vascular lesions and dopaminergic denervation (DD) (VP+DD group); and the third group consisted of patients with dopaminergic denervation (PD group) without vascular lesions. All patients underwent neurological and neuropsychological assessments. The groups differed in disease duration, age at onset, and cerebrovascular risk factors. The VP and VP+DD groups performed worse than the PD group on frontal/executive tasks. Regardless of the presence of dopaminergic denervation, cerebrovascular lesions in hemispheric white matter, basal ganglia, and cerebellum have an important effect in determining early onset and severity of cognitive impairment in patients with parkinsonism. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Italian Ministry of University and Research - No. MIUR‐2006065350‐003; </note><subject lang="en"><genre>Keywords</genre><topic>cerebrovascular lesions</topic><topic>dopaminergic denervation</topic><topic>cognitive functions</topic><topic>frontal lobe functions</topic><topic>Parkinson's disease</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>50</start><end>56</end><total>7</total></extent></part></relatedItem><identifier type="istex">CA49CDA1F1BC87C5782A64365503D6CC51681E1A</identifier><identifier type="DOI">10.1002/mds.22893</identifier><identifier type="ArticleID">MDS22893</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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